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Chapter 10: Stimuli-Responsive Nanotheranostics.

Basit Yameen, Jun Wu, Cristian Vilos, Andrew Whyte, David Werstler, Lori Pollit , Omid C. Farokhzad. Nanotheranostics for Personalized Medicine: 267-296. World Scientific, 2016.


  1. María Francisca Matus, Cristian Vilos, Bruno A. Cisterna, Eduardo Fuentes, Iván Palomo. Nanotechnology and primary hemostasis: differential effects of nanoparticles on platelet responses. Vascular Pharmacology. accepted

  2. Johanna Abrigo, Fabian Campos, Felipe Simon, Claudia Riedel, Daniel Cabrera, Cristian Vilos, Claudio Cabello-Verrugio. TGF-β requires the activation of canonical and non-canonical signalling pathways to induce skeletal muscle atrophy. Biological Chemistry. accepted

  3. Choi WI, Sahu A, Vilos C, Kamaly N, Jo SM, Lee JH, Tae G. Bioinspired Heparin Nanosponge Prepared by Photo-crosslinking for Controlled Release of Growth Factors. Sci Rep. 2017 Oct 30;7(1):14351.

  4. Roa Henríquez, I., Cantín, M., Vilos, C., Rosas, C., Lemus, D. Angiogenesis and tumor progression inhibition of cyclooxygenase-2 selective inhibitor celecoxib associated with poly (Lactic-co-glycolic acid) in tumor cell line resistant to chemotherapy. (2017) International Journal of Morphology, 35 (2), pp. 733-739.

  5. Peñaloza JP, Márquez-Miranda V, Cabaña-Brunod M, Reyes-Ramírez R, Llancalahuen FM, Vilos C, Maldonado-Biermann F, Velásquez LA, Fuentes JA, González-Nilo FD, Rodríguez-Díaz M, Otero C. Intracellular trafficking and cellular uptake mechanism of PHBV nanoparticles for targeted delivery in epithelial cell lines. J Nanobiotechnology. 2017 Jan 3;15(1):1

  6. Mauricio P. Pinto, Maximiliano Arce, Basit Yameen, Cristian Vilos. Targeted brain delivery nanoparticles for malignant gliomasNanomedicine (Lond). 2017 Jan;12(1):59-72.

  7. Won Il Choi, Basit Yameen, Cristian Vilos, Abhishek Sahu, Seong-Min Jo, Daekyung Sung, Giyoong Taee. Optimization of Fibrin Gelation for Enhanced Cell Seeding and Proliferation in Regenerative Medicine Applications. Polymers for Advanced Technologies. 2017, 28: 124–129.

  8. Eduardo Fuentes, Basit Yameen, Soung- Jae Bong, Carolina Salvador-Morales, Ivan Palomo, Cristian Vilos. Antiplatelet effect of differentially charged PEGylated lipid-polymer nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine. [Epub ahead of print]

  9. Bruno A. Cisterna, Nazila Kamaly, Won Il Choi, Ali Tavakkoli, Omid C. Farokhzad, Cristian Vilos. Targeted nanoparticles for colorectal cancer. Nanomedicine (Lond). 2016 ,Vol. 11, No. 18, Pages 2443-2456.

  10. Won Il Choi, Abhishek Sahu, Cristian Vilos, Jong Hyun Lee, Sunghyun Kim, Young Ki Hong, Donggeun Sul, Sunwook Hwang, Sang Heon Lee, Giyoong Tae. Chitosan functionalized thermosponge nano-carriers for prolonged retention and local delivery of chymopapain at the nucleus pulposus in porcine discs ex vivoRSC Advances. 2016, 6, 90967-90972.

  11. Salvador Morales, Carolina; Brahmbhatt, Binal; Márquez-Miranda, Valeria; Araya-Duran, Ingrid; Canan, Jonathan; Gonzalez-Nilo, Fernando; Vilos, Cristian; Cebral, Juan; Mut, Fernando; Lohner, Rainald; Leong, Brian; Sundaresan, Gobalakrishnan ; Zweit, Jamal. Mechanistic Studies on the Self-assembly of PLGA Patchy Particles and their Potential Applications in Biomedical ImagingLangmuir2016, 32 (31), pp 7929–7942

  12. Oscar Valdés Lizama and Cristian Vilos, Esteban F Durán‐Lara. Techniques of structural characterization of dendrimers. Current Organic Chemistry. 2016 ,Vol. 20, No. 24, Pages 2591-2605.

  13. Nazila Kamaly, Gabrielle Fredman, Jhalique Jane R. Fojas, Manikandan Subramanian, Won II Choi, Katherine Zepeda, Cristian Vilos, Mikyung Yu, Suresh Gadde, Jun Wu, Jaclyn Milton, Renata Carvalho Leitao, Livia Rosa Fernandes, Moaraj Hasan, Huayi Gao, Vance Nguyen, Jordan Harris, Ira Tabas, and Omid C Farokhzad. Targeted Interleukin-10 Nanotherapeutics Developed with a Microfluidic Chip Enhance Resolution of Inflammation in Advanced Atherosclerosis. ACS Nano, 2016, 10 (5), pp 5280–5292.

  14. Bahamonde-Norambuena D, Molina-Pereira A, Mario Cantin, Zepeda Katherine, Muñoz Mariela, Cristian Vilos. Polymeric nanoparticles in dermocosmeticInt. J. Morphol., 33(4):1563-1568, 2015.

  15. Mariela Muñoz, Cristian Vilos, Mario Cantín. Prothrombin C20209T mutation in deep vein thrombosis: a case report. Int J Clin Exp Med 2015;8(7):11225-11229.

  16. B. Yameen, C. Vilos, W.I. Choi, A. Whyte, J. Huang, L. Pollit, O.C. Farokhzad. Drug delivery nanocarriers from fully degradable PEG-conjugated polyester with reduction-responsive backbone. Chem. Eur. J. 2015, 21,1–6.

  17. Cristian Vilos, Luis A Velasquez, Paula I Rodas, Katherine Zepeda, Soung-Jae Bong, Natalia Herrera, Mario Cantin, Felipe Simon, Luis Constandil. Preclinical development and in vivo efficacy of ceftiofur-PLGA microparticles. 2015. Plos One, 10(4): e0123335.

  18. Paula Solar, Guillermo González, Cristian Vilos, Natalia Herrera, Natalia Juica, Mabel Moreno, Felipe Simon and Luis VelásquezMultifunctional polymeric nanoparticles doubly loaded with SPION and ceftiofur retain their physical and biological properties. Journal of Nanobiotechnology (2015) 13:14

  19. Choi, Won; Kamaly, Nazila; Riol-Blanco, Lorena; Lee, In-Hyun; Wu, Jun; Swami, Archana; Vilos, Cristian; Yameen, Basit; Yu, Mikyung; Shi, Jinjun; Tabas, Ira; von Andrian, Ulrich; Jon, Sangyong; Farokhzad, Omid C. A Solvent-free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins. Nano Letters. Nan.o Lett. 2014 Nov 12;14(11):6449-55

  20. Yameen B, Choi WI, Vilos C, Swami A, Shi J, Farokhzad OC. Insight into nanoparticle cellular uptake and intracellular targetingJournal of Controlled Release 190 (2014) 485–499.  

  21. Vilos, C., L. Constandil, P. I. Rodas, M. Cantin, K. Zepeda, N. Herrera, and L. A. Velasquez. Evaluation of ceftiofur–PHBV microparticles in ratsDrug Design, Development and Therapy 2014:8 651–666.

  22. Vilos CNanotechnology in Preclinical and Clinical Drug DevelopmentInt. J. Med. Surg. Sci., 1(1):73-93, 2014.

  23. Mario Cantín, Patricio Miranda, Iván Suazo Galdames, Daniela Zavando, Patricia Arenas, Luis Velásquez, Cristian Vilos. In vivo biocompatibility of the PLGA microparticles in parotid gland. Int J Clin Exp Pathol. 2013;6(11):2412-2418.

  24. Vilos Cristian, Gutiérrez Marlen, Escobar Roberto A, Morales Francisco, Denardin Juliano C, Velasquez Luis, Altbir Dora. Superparamagnetic Poly (3-hydroxybutyrate-co-3 hydroxyvalerate) (PHBV) nanoparticles for biomedical applications. Electron. J. Biotechnol. 2013. 16(5): 8-8.

  25. Vilos C, Morales FA, Solar PA, Herrera NS, Gonzalez-Nilo FD, Aguayo DA, Mendoza HL, Comer J, Bravo ML, Gonzalez PA, Kato S, Cuello MA, Alonso C, Bravo EJ, Bustamante EI, Owen GI, Velasquez LA. Paclitaxel-PHBV nanoparticles and their toxicity to endometrial and primary ovarian cancer cells. Biomaterials. 2013; 34(16):4098-108.

  26. Vilos C., Constandil L., Herrera N., Solar P., Escobar J., Velásquez L. A. Ceftiofur-loaded PHBV microparticles: a potential formulation for a long-acting antibiotic to treat animal infections. Electronic Journal Biotechnology. Vol 15, No 4 (2012).

  27. Vilos C. and Velasquez L. A., Therapeutic Strategies Based on Polymeric Microparticles, Journal of Biomedicine and Biotechnology, vol. 2012, Article ID 672760, 9 pages, 2012.

  28. Shi J., Xiao Z., Votruba A. R., Vilos C., and Farokhzad O. C. Differentially Charged Hollow Core/Shell Lipid–Polymer–Lipid Hybrid Nanoparticles for Small Interfering RNA Delivery. Angew. Chem. Int. Ed. 2011, 50,   1 – 6.

  29. Tapia A, Vilos C, Marín JC, Croxatto HB, Devoto L. Bioinformatic detection of E47, E2F1 and SREBP1 transcription factors as potential regulators of genes associated to acquisition of endometrial receptivity. Reprod Biol Endocrinol. 2011; 9: 14.

  30. Acuña, L.; Suazo, G. I; Zavando, D.; Elgueta, S.; Velásquez, L.; Vilos, C. & Cantín, M. Morphometric and histopathologic changes in skeletal muscle induced for injectable PLGA microparticles. Int. J. Morphol. 29(2):403-408, 2011.

  31. Cantín, M.; Vilos, C. & Suazo, G. I. Nanodentistry: the Future of Dentistry Based on Nanotechnology Systems. Int. J. Odontostomat., 4(2):127-132, 2010.

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